个人简介:
刘朗夏博士，教授，博士生导师。在巴黎血管与血液研究所及法国国家健康与医学研究院担任研究员。从2008年7月起被暨南大学聘为教授，博导，为广东省高校“千百十”工程省级培养对象。研究领域涉及蛋白质之间的相互作用及其功能、癌症发病、破骨细胞分化、病原微生物致病等过程的分子机制。以（共同）通讯作者或第一作者发表SCI收录论文34篇，文章被引用总数超2000次（截止2024年4月）。早年在法国主持欧盟第六框架研究计划子项目和欧洲脑白质失养症协会的研究基金。近年来承担国家重点基础研究发展计划“973”子项目、广东省自然科学基金等项目。是法国国家艾滋病研究学会(ANRS)奖及Rhone-Poulenc-Rorer企业奖的获得者。担任国家和广东省自然科学基金项目的网评委员，和多个省市级项目的评审委员，多种国际学术期刊的审稿人。
职称/职务：教授
研究方向：癌症，蛋白质相互作用与功能，细胞分化，细胞程序性死亡，微生物致病
学习经历：
(1) 1994-09 至 1998-07, 法国巴黎第七大学, 生物化学, 博士
(2) 1992-09 至 1994-07, 法国巴黎第六大学, 生物, 硕士
(3) 1989-09 至 1992-07, 法国巴黎第七大学, 生物化学, 学士
(4) 1984-09 至 1988-07, 暨南大学, 生物, 学士
工作经历：
(1) 2008-07 至 今, 暨南大学, 生命科学技术学院, 教授
(2) 2004-04 至 2007-12, 法国国立健康与医学研究院, Cochin研究所传染病部, 研究员
(3) 2001-01 至 2004-03, 法国巴黎血管与血液研究所, 第4研究团队, 研究员
主要论文：
A. 近五年以通讯作者发表的主要论著:
[1] Xiong Dan, Geng Chengjie, Zeng Liyi, Yao Hua, Tan Jiewen, Zhang Lan, Liu Xiaohui, Liu Langxia*. Artesunate induces ferroptosis by regulating MT1G and has an additive effect with doxorubicin in diffuse large B-cell lymphoma cells. Heliyon. 2024, 10(7):e28584.
[2] Gao Xue, Lian Qionghua, Guan Baiye, Liu QiuYun, Meng Meng, Chen Yang, Jin Jingjie, Li Huihua, Liu Xiaohui, Sun Zhenghua, Liu Langxia*, He QingYun, Zhang Gong. ZSWIM1 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma Cells through the STK38/MEKK2/ERK1/2 Axis. J Proteome Res. 2023, 22(4):1080-1091.
[3] Zheng Xiaofen, Huang Donglan, Liu Xiaohui, Liu QiuYun, Gao Xuejuan, Liu Langxia*. GSK3β/ITCH/c-FLIP Axis Counteracts TRAIL-induced Apoptosis in Human Lung Adenocarcinoma Cells. Protein Pept Lett. 2023, 30(3):242-249.
[4] Meng Meng, Lu Meizhi, Feng Junxia, Zhou Xiaoying, Meng Ping, Chen Luxuan , Zou Xunliang, Liu Xiaohui, Liu Langxia*, Gao Xuejuan, Zhang Yunfang. Exosomal PPARγ derived from macrophages suppresses LPS-induced peritonitis by negative regulation of CD14/TLR4 axis. Inflamm Res. 2023, 72(8):1567-1581.
[5] Liu Xiaohui, Li Lu, Geng Chengjie , Wen Shiyuan, Zhang Cuiqiong, Deng Chunmiao, Gao Xuejuan, Zhang Gong, He Qing-Yu, Liu Langxia*. DDX17 promotes the growth and metastasis of lung adenocarcinoma. Cell Death Discov. 2022, 8(1):425.
[6] Zhang Huan-Tian, Zeng Qingzhong, Wu Baomeng, Lu Junlei, Tong Kui-Leung, Lin Jiebin, Liu Qiu-Yu , Xu Lipei, Yang Jie, Liu Xiaohui, Liu Wanting, Zhang Yun-Fang, Lian Qionghua, Liu Langxia*, Gao Xuejuan. TRIM21-regulated Annexin A2 plasma membrane trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated autophagy. Cell Death Dis. 2021 Jan 6;12(1):21.
[7] Liu Xiaohui, Huang Xiuzhu, Ma Jie, Li Lu, Hu Huifan, Feng Junxia, Gao Xuejuan, Zhang Yunfang, Liu Langxia*. 3'untranslated regions (3'UTR) of Gelsolin mRNA displays anticancer effects in non-small cell lung cancer (NSCLC) cells. Am J Cancer Res. 2021, 11(8):3857-3876.
[8] Deng Chunmiao, Liu Xiaohui, Zhang Cuiqiong, Li Lu, Wen Shiyuan, Gao Xuejuan, Liu Langxia*. ANXA1-GSK3β interaction and its involvement in NSCLC metastasis. Acta Biochim Biophys Sin (Shanghai). 2021, 53(7):912-924.
[9] Tang Donge, Liu Xiaohui, Chen Kezhi, Li Zhipeng, Dai Yong, Xu Jiake, Zhang Huan-Tian, Gao Xuejuan , Liu Langxia*. Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation. Aging (Albany NY). 2020, 12(13):13297-13317.
[10] Liu Xiaohui, Tang Donge, Dai Yong, Gao Xuejuan, Liu Langxia*. PCNA and GSK3β interact with each other to regulate H1299 lung adenocarcinoma cells apoptosis. Neoplasma, 2020, 67(1):15-26.
[11] Liu Xiaohui, Ma Jie, Feng Junxia, Zhang Yunfang*, Liu Langxia*. Regulation and related mechanism of GSN mRNA level by hnRNPK in lung adenocarcinoma cells. Biol Chem. 2019, 400(7):951-963.
[12] Xu Lipei, Zhang Tingting, Huang Wensi, Liu Xiaohui, Lu Junlei, Gao Xuejuan, Zhang Yun-Fang, Liu Langxia*. YAP mediates the positive regulation of hnRNPK on the lung adenocarcinoma H1299 cell growth. Acta Biochim Biophys Sin (Shanghai). 2019 Jul 10;51(7):677-687. doi: 10.1093/abbs/gmz053. PMID: 31187136.
B. 其他年份发表的文章：
[13] Li Zhipeng, Liu Xiaohui*, Ma Jie, Zhang Tingting, Gao Xuejuan, Liu Langxia*. hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293 cells. Int. J. Oncol. 2018, 53:2200-12.
[14] Wang Cuihua, Chen Kezhi, Liao Shengyou, Gu Wei, Lian Xinlei, Zhang Jing, Gao Xuejuan, Liu Xiaohui, Wang Tong, He Qingyu, Zhang Gong, Liu Langxia*. The flightless I protein interacts with RNA-binding proteins and is involved in the genome-wide mRNA post-transcriptional regulation in lung carcinoma cells. Int. J. Oncol. 2017, 51:347-61.
[15] Lu Wen-hui, Shi Yu-xun, Ma Zheng-lai, Wang Guang, Liu Langxia, Chuai Manli, Song Xiaoyu, Münsterberg Andrea, Cao Liu, Yang Xuesong. Proper autophagy is indispensable for angiogenesis during chick embryo development. Cell Cycle 2016, 15:1742-54.
[16] Gao Xuejuan, Xu Fengmei, Zhang Huan-Tian, Chen Miaojuan, Huang Wensi, Zhang Qihao, Zeng Qingzhong, Liu Langxia*. PKCα–GSK3β–NF-κB signaling pathway and the possible involvement of TRIM21 in TRAIL-induced apoptosis. Biochem. Cell Biol. 2016, 94:256-64.
[17] Gao Xuejuan, Feng Junxia, He Yujiao, Xu Fengmei, Fan Xiaoqin, Huang Wensi, Xiong Haiting, Liu Qiuyu, Liu Wanting, Liu Xiaohui, Sun Xuesong, He Qing-Yu, Zhang Qihao*, Liu Langxia*. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci. Rep. 2016, 6:22999-99.
[18] Fan Xiaoqin, Xiong Haiting, Wei Jinmei, Gao Xuejuan, Feng Yuan, Liu Xiaohui, Zhang Gong, He Qingyu*, Xu Jiake*, Liu Langxia*. Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation. Sci. Rep. 2016, 5:17732-32.
[19] Wang Cuihua, Gao Xuejuan, Liao Shengyou, Feng Junxia, Luo Bin, Liu Langxia*. Transcriptome analysis of human breast cancer cell lines MCF-7 and MDA-MB- 435 by RNA-seq. Mol. Biol. 2015, 49:244-52.
[20] Gao Xuejuan, Dan Songsong, Xie Yingying, Qin Huanhuan, Tang Donge, Liu Xiaohui, He Qingyu, Liu Langxia*. 14‐3‐3ζ Reduces DNA Damage by Interacting With and Stabilizing Proliferating Cell Nuclear Antigen. J. Cell. Biochem. 2015, 116:158-69.
[21] Fan Xiaoqin, Wei Jinmei, Xiong Haiting, Liu Xiaohui, Benichou Serge, Gao Xuejuan*, Liu Langxia*. A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction. Int. J. Oncol. 2015, 47:1485-93.
[22] Li Nan, Yang Xiao-Yan, Guo Zhong, Zhang Jing, Cao Kun, Han Junlong, Zhang Gong, Liu Langxia, Sun Xuesong, He Qing-Yu. Varied metal-binding properties of lipoprotein PsaA in Streptococcus pneumoniae. JBIC. 2014, 19:829-38.
[23] Gao Xue Juan, Feng Jun Xia, Zhu Sen, Liu Xiao Hui, Tardieux Isabelle, Liu Langxia*. Protein Phosphatase 2C of Toxoplasma Gondii Interacts with Human SSRP1 and Negatively Regulates Cell Apoptosis. Biomed. Environ. Sci. 2014, 27:883-93.
[24] Gao Xuejuan, He Yujiao, Gao Lingmei, Feng Junxia, Xie Yingying, Liu Xiaohui, Liu Langxia*. Ser9-phosphorylated GSK3β induced by 14-3-3ζ actively antagonizes cell apoptosis in a NF-κB dependent manner. Biochem. Cell Biol. 2014, 92:349-56.
[25] Chen Miaojuan, Liu Tengfei, Xu Lina, Gao Xuejuan, Liu Xiaohui, Wang Cuihua, He Qingyu, Zhang Gong, Liu Langxia*. Direct Interaction of 14-3-3ζ with Ezrin Promotes Cell Migration by Regulating the Formation of Membrane Ruffle. J. Mol. Biol. 2014, 426:3118-33.
[26] Chen Miaojuan, Gao Xuejuan, Xu Lina, Liu Tengfei, Liu Xiaohui, Liu Langxia*. Ezrin is required for epithelial-mesenchymal transition induced by TGF-β1 in A549 cells. Int. J. Oncol. 2014, 45:1515-22.
[27] Gao Xuejuan, Wang Jianying, Gao Lingmei, Yin Xingfeng, Liu Langxia*. Identification and analysis of glycogen synthase kinase 3 beta1 interactome. Cell Biol. Int. 2013, 37:768-79.
[28] Yan Guangrong, Xu Songhui, Tan Zilu, Liu Langxia, He Qingyu. Global identification of miR‐373‐regulated genes in breast cancer by quantitative proteomics. Proteomics 2011, 11:912-20.
[29] Li Liping, Lu Chunhua, Chen Zhipeng, Ge Feng, Wang Tong, Wang Wei, Xiao ChuanlLe, Yin Xinfeng, Liu Langxia, He Jianxing. Subcellular proteomics revealed the epithelial–mesenchymal transition phenotype in lung cancer. Proteomics. 2011, 11:429-39.
[30] Lemay Julie, Maidoupeindara Priscilla, Cancio Reynel, Ennifar Eric, Coadou Gael, Maga Giovanni, Rain Jeanchristophe, Benarous Richard, Liu Langxia*. AKAP149 Binds to HIV-1 Reverse Transcriptase and Is Involved in the Reverse Transcription. J. Mol. Biol. 2008, 383:783-96.
[31] Lemay Julie, Maidoupeindara Priscilla, Bader Thomas, Ennifar Eric, Rain Jeanchristophe, Benarous Richard, Liu Langxia*. HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells. Retrovirology 2008, 5:47-47.
[32] Hainaud Patricia, Contreres Jeanolivier, Villemain Aude, Liu Langxia, Plouet Jean, Tobelem Gerard, Dupuy Evelyne. The Role of the Vascular Endothelial Growth Factor–Delta-like 4 Ligand/Notch4-Ephrin B2 Cascade in Tumor Vessel Remodeling and Endothelial Cell Functions. Cancer Res. 2006, 66:8501-10.
[33] Liu LangXia, Heveker Nikolaus, Fackler Oliver T, Arold Stefan, Le Gall Sylvie, Janvier Katy, Peterlin B Matija, Dumas Christian, Schwartz Olivier, Benichou Serge. Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions. J. Virol. 2000, 74:5310-19.
[34] Selig L, Pages J-C, Tanchou V, Preveral S, Berlioz-Torrent C, Liu Lang Xia, Erdtmann L, Darlix J-L, Benarous R, Benichou S. Interaction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentiviruses. J. Virol. 1999, 73:592-600.
[35] Liu Lang Xia, Janvier Katy, Berteaux-Lecellier Véronique, Cartier Nathalie, Benarous Richard, Aubourg Patrick. Homo-and heterodimerization of peroxisomal ATP-binding cassette half-transporters. J. Biol. Chem. 1999, 274:32738-43.
[36] Le Gall Sylvie, Erdtmann Lars, Benichou Serge, Berlioz-Torrent Clarisse, Liu Langxia, Benarous Richard, Heard Jean-Michel, Schwartz Olivier. Nef interacts with the μ subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 1998, 8:483-95.
[37] Liu Lang Xia, Margottin Florence, Le Gall Sylvie, Schwartz Olivier, Selig Luc, Benarous Richard, Benichou Serge. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. J. Biol. Chem. 1997, 272:13779-85.
[38] Benichou S, Liu LangXia, Erdtmann L, Selig L, Benarous R. Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein. Res. Virol. 1997, 148:71-73.
[39] Margottin Florence, Benichou Serge, Durand Hervé, Richard Virginie, Liu Lang Xia*, Gomas Emmanuel, Benarous Richard. Interaction between the Cytoplasmic Domains of HIV-1 Vpu and CD4: Role of Vpu Residues Involved in CD4 Interaction andin VitroCD4 Degradation. Virology 1996, 223:381-86.
承担课题：
[1] 广东省自然科学基金面上项目，FAM210B基因在肺腺癌生长与转移中的功能和机制研究，10万元，2023-01-01 至 2025-12-31，编号：2023A15150102482，项目负责人。
[2] 2023年度广东省大学生创新创业训练计划项目创新训练项目一般项目， 青蒿琥酯联合多柔比星抗ABC型弥漫性大B细胞淋巴瘤及其机制研究，1万元，2023.03-2024.02，编号：S202310559130，项目导师。
[3] 广东省自然科学基金面上项目，GSN（凝溶胶蛋白）mRNA的 3’UTR在肺腺癌细胞中的功能及分子机制研究，10万元，2019.10-2022.9，编号：2019A1515010182，项目负责人。
[4] 科技部“973”项目课题, “结肠癌及其相关巨噬细胞的分泌蛋白质组与肿瘤发展的相关性研究”, 37万元, 2011.3-2016.2, 编号：2011CB910701，子课题的项目负责人。
[5] 广东省自然科学基金研究团队项目，“功能蛋白质研究与抗癌药物靶标发现”，60万元，2014.1-2018.12，编号：S2013030013315，核心成员。
[6] 广东省自然科学基金面上项目，“hnRNPK与GSK3β协同稳定c-FLIP蛋白从而拮抗TRAIL诱导的肿瘤细胞凋亡”，10万元，2016.6-2019.5，编号：2016A030313083，项目负责人。
[7] 广州市科技计划项目科学（技术）研究专项一般项目，“GSK3β与hnRNPK的相互作用参与TRAIL诱导肿瘤细胞凋亡的机制研究”，20万元，2016.4-2019.3，编号：201607010175，项目负责人。
[8] 广东省高等学校高层次人才项目，“14-3-3z蛋白参与肿瘤发生发展和转移的新机制研究：从新靶点的鉴定和确认到新药开发”，25万元，2011.1-2014.12，编号：粤财教【2011】431号，项目负责人。
[9] 广东省自然科学基金面上项目，“刚地弓形虫蛋白磷酸酶2C的细胞辅助因子的研究”，10万元，2009.10-2011.9，编号：9151065004000005，项目负责人。
[10] 欧盟第六研究与发展框架计划研究基金，20万欧元，2004-2007，子项目负责人。
[11] 欧洲脑白质失养症协会研究基金，19.4万法郎，1998-2000，项目负责人。
授权专利：何庆瑜; 高学娟; 张弓; 官柏烨; 连琼华; 刘朗夏; ZSWIM1蛋白在调控肺腺癌细胞增殖和转移中的应用, 2023-04-25, 中国, CN202111485057.1
讲授课程：参与硕士生选修课程《功能蛋白研究》、《细胞信号通路理论与技术》、《基因组学与蛋白组学》和博士生选修课程《功能蛋白研究》、《生物学前沿》、《生物化学》的授课。
荣誉奖励：
1. 2010年入选广东省千百十计划第六批省级培养对象
2. 2011年获得广东省高等学校高层次人才项目
3. 1999年获得中法科学技术促进协会NG Tatman奖
4. 1998年获得法国国家爱滋病研究学会(ANRS)奖
5. 1997年获得Rhone-Poulenc-Rorer奖
电子邮箱：tliulx@jnu.edu.cn
办公电话：020-85222573
办公地址：广州市天河区黄埔大道西601号暨南大学第二理工楼919
